GLP-1 medications, fertility and IVF

6 March 2026

Julija Gorodeckaja

By Dr Julija Gorodeckaja, Fertility Specialist and Gynaecologist, The Evewell Harley Street

In recent months, many fertility patients have been asking an important and increasingly common question:

• Can I take Ozempic or Mounjaro while trying to conceive?
• Does a GLP-1 affect IVF success?
• Should I stop Mounjaro before egg freezing?
• Are GLP-1 injections safe during fertility treatment?

These medications are becoming more widely used, both for diabetes management and for weight loss, and it’s completely understandable that patients planning pregnancy, IVF, IUI or egg freezing want clear information.

This article explains what GLP-1 medications are, how they work, and what’s currently advised for people undergoing fertility treatment.

What are GLP-1 medications?

GLP-1 medications are prescription drugs that help regulate appetite and blood sugar. GLP-1 stands for glucagon-like peptide 1, a natural hormone produced in the gut that plays a role in:

• Insulin release
• Blood glucose control
• Appetite regulation
• Slowing gastric emptying (how quickly the stomach empties)

These medications have become well known for their effects on weight loss, but they were originally developed for type 2 diabetes.

Common GLP-1 drug names patients ask about

Some of the most frequently prescribed GLP-1 medications include:

Semaglutide brands

• Ozempic
• Wegovy
• Rybelsus

Tirzepatide brands

• Mounjaro

Liraglutide brands

• Saxenda
• Victoza

At The Evewell, we often see patients using these medications before starting IVF or egg freezing, particularly where weight management or metabolic health is part of their journey.

How do GLP-1s work?

GLP-1 medications support weight loss and metabolic health by:

• Reducing appetite and cravings
• Helping patients feel full sooner
• Improving insulin sensitivity
• Lowering blood sugar levels
• Slowing gastric emptying

That last point is especially important in fertility treatment, because delayed gastric emptying can affect sedation safety during procedures such as egg collection.

Do GLP-1 medications improve fertility?

This is a very common question, especially for patients with PCOS or insulin resistance. Some people may notice improved ovulation or cycle regularity after weight loss or improved metabolic control.

However, GLP-1 medications aren’t fertility drugs, and they aren’t prescribed as a direct fertility treatment. Their role is usually part of a broader health picture.

If you’re considering GLP-1s for fertility reasons, it’s essential to discuss this with both your GP and fertility specialist.

Can I take Ozempic, Wegovy or Mounjaro during IVF?

The current guidance is that GLP-1 medications should be stopped before pregnancy and before key stages of fertility treatment, because the effects on pregnancy aren’t fully known. This includes treatment such as:

• IVF
• IUI
• Embryo transfer
• Egg freezing
• Preparing to conceive naturally

Why do GLP-1s need to be stopped before egg collection sedation?

Egg collection is typically performed under sedation. GLP-1 medications slow stomach emptying, increasing the risk of reflux or regurgitation during sedation, which can compromise the airway.

For this reason, The Evewell guidance advises that patients should stop GLP-1 medications at least 4 weeks before sedation procedures, including egg collection.

When should GLP-1 medications be stopped before trying to conceive?

The MHRA and current clinical guidance recommend specific washout periods for each medication.

Semaglutide (Ozempic, Wegovy, Rybelsus)

• Stop at least 2 months before pregnancy.
  

Tirzepatide (Mounjaro)

• Stop at least 1 month before pregnancy.
  

Liraglutide (all brands)

• These leave the body more quickly and should be stopped just before trying to conceive.
  

This is relevant if you plan to have an embryo transfer or insemination, and you should always discuss timing with your consultant.

Important medical caveat

This article is for general information only and isn’t medical advice. GLP-1 medications are prescription drugs that must always be taken under appropriate medical supervision. If you’re currently taking a GLP-1 medication, or considering one, and you’re:

• Trying to conceive
• Planning IVF or IUI
• Preparing for egg freezing
• Thinking about embryo transfer

You must speak to your GP, prescribing clinician, and fertility specialist before making any changes. You shouldn’t stop or start prescription medication without medical guidance.

Support during fertility treatment

Fertility treatment can be stressful and anxiety-provoking, and questions around medication are very common.

At The Evewell, all patients are offered access to supportive counselling and guidance throughout their treatment journey. If you’re unsure about GLP-1 medications and your treatment timeline, please speak to your consultant team.